By S. S. Easter Jr., G. N. Nicola, J. D. Burrill (auth.), Leo M. Chalupa, Barbara L. Finlay (eds.)
Development and association of the Retina deals a useful survey of up to date examine concerns and techniques facing the retina and retinal projections.
The book's 19 chapters file on investigations into parts: learn into the association of the mature retina and paintings on developmental matters. A sampling of bankruptcy issues contains -- embryonic patterning of cone subtypes within the mammalian retina -- synaptic transmission among retinal neurons -- scaling the retina, macro and micro -- retinal ganglion cellphone axonal delivery, and more.
Read or Download Development and Organization of the Retina: From Molecules to function PDF
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Extra info for Development and Organization of the Retina: From Molecules to function
1996). , 1993), our analysis of cone patterning in the mouse reveals that manipulating embryonic retinoid levels changes the proportion of cones expressing a wavelength-sensitive opsin, but not overall cone number. These findings indicate that retinoid manipulations regulate the differentiation of embryonic cells into specific cone subtypes rather than cone genesis or survival. For example, citral treatment at E8 decreased expression of the MWS opsin in dorsal retina and increased expression of the MWS opsin in ventral retina.
Alternatively, the longer gestation period in the mouse may allow for the temporal resolution of retinoid-induced perturbations of retinal development, not observed in zebrafish. Our results suggest that RA may independently regulate the formation of the optic stalk, the dorsal/ventral growth of the retina, and the regional restriction of transcription factors in the embryonic murine retina. RA and citral given prior to the onset of cone genesis altered the regional expression of the RARE-tk-lacZ transgene, but not of transcriptional markers of dorsal and ventral retina, suggesting that the pattern of retinoid responsiveness is not directly correlated with the establishment of the dorsoventral axis.
Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord. Dev. Dyn. 204, 1- 12. , Linney, E. -S. (1993). Local sources ofretinoic acid coincide with retinoid-mediated transgene activity during embryonic development. Proc. Natl. Acad. Sci. USA 90, 6572--6576. Retinoids and Cone Patterning 39 Crowe, D. , Gudas, L. , and Rheinwald, J. G. (1991). Variable expression ofretinoic acid receptor beta (RARP) mRNA in human oral and epidermal keratinocytes; relation to keratin 19 expression and keratinization potentia!.
Development and Organization of the Retina: From Molecules to function by S. S. Easter Jr., G. N. Nicola, J. D. Burrill (auth.), Leo M. Chalupa, Barbara L. Finlay (eds.)