By Ronald Marks, James J. Leyden
This article deals the busy dermatologist an updated evaluate of advancements within the administration and remedy of dermatologic issues. Dermatologic treatment in present perform explores not just the examine theories that experience lately emerged, but in addition the sensible program of that study in normal medical perform. a number of themes is explored, together with new drug cures, surgical advances and the administration of definite universal pores and skin difficulties, reminiscent of psoriasis, rosacea, pores and skin melanoma and zits. This quantity is integral for each dermatologist, health care professional and plastic general practitioner, and it truly is beneficial for complicated scholars in dermatology.
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Extra info for Dermatologic therapy in current practice
J Am Acad Dermatol 1986: 14; 221–5. 23. Kligman AM, Fulton JE Jr, Plewig G, Topical vitamin A acid in acne vulgaris. Arch Dermatol 1969: 99; 469–76. 24. Leyden JJ, Marples RR, Mills OH, Kligman AM, Tretinoin and antibiotic therapy in acne vulgaris. South Med J 1974: 67; 20–5. 25. Shroot B, Michel S, Pharmacology and chemistry of adapalene. J Am Acad Dermatol 1997: 36; 5 96–103. 26. Nagpal S, Athanikar J, Chandraranta RAS, Separation of transactivation and AP1 antagonism functions of retinoic acid receptor alpha.
Azelaic acid and metronidazole have no in vivo effects and their antiacne effects are due to non-antibacterial effects. For systemic agents, minocycline is clearly the most effective agent with doxycycline (a lipophilic molecule) at 200 mg equivalent to 1 g of the less-lipophilic tetracycline hydrochloride. Trimethoprimsulfamethoxazole is also a very effective agent but is used less frequently because of the risk of severe drug reactions. Urticarial and serum sickness reactions are uncommon but appear to be more common with minocycline.
Berth-Jones J, Graham-Brown RAC, Marks R et al, Long-term efficacy and safety of cyclosporin in severe adult atopic dermatitis. Br J Dermatol 1997: 136; 76–81. ch02 7/9/01 32 11:01 am Page 32 Dermatologic Therapy in Current Practice 33. Rothe MJ, Grant-Kels JM, Atopic dermatitis: an update. J Am Acad Dermatol 1996: 35; 1–13. 34. Goto T, Kino S, Hatanaka H et al, FK506: historical perspectives. Transplant Proc 1991: 23; 2713–17. 35. Ruzicka T, Bieber T, Schöpf E et al, A short-term trial of tacrolimus ointment for atopic dermatitis.
Dermatologic therapy in current practice by Ronald Marks, James J. Leyden