By Mario E. Lacouture
This can be the 1st booklet to target common and regularly disabling unwanted effects concerning the surface, hair, and nails in melanoma sufferers. It offers distinctive descriptions of mechanism-of-action in all present oncology medications and the scientific presentation and mechanisms underlying their dermatologic unwanted effects, along rigorously offered therapy concepts, permitting physicians to noticeably increase their care of sufferers with melanoma. while present oncology and dermatology textbooks in basic terms in brief take care of this subject, this source deals dermatologists and different practitioners a concentrated point of view on cancer-related dermis stipulations.
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Extra info for Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients
Chemotherapeutics represent the most common causes of anagen effluvium. As most hair follicles are in the anagen stage at any given time, anagen effluvium affects the majority of scalp hair. Hair is further classified according to size. Terminal hairs are at least 60 μm in diameter and are found on the scalp, eyebrows, and eyelashes at birth. The length of the terminal hair is determined by the duration of the anagen growth phase. Vellus hairs are less than 30 μm in diameter and typically do not achieve a length greater than 2 cm.
The predominant cell types within the dermis include fibroblasts, macrophages, mast cells, and circulating cells of the immune system. Mesenchymally derived fibroblasts synthesize and degrade connective tissue matrix proteins which provide the structural framework for the dermis. Bone marrow derived macrophages differentiate into circulating monocytes and migrate to the dermis before differentiating further in tissue. Macrophages in the skin serve a number of important functions including antigen processing and presentation, phagocytosis, and wound healing.
Barasch, A. (2010) Oral mucositis. Oral Oncology, 46, 452–456. , Keefe, D. et al. (2004) Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer, 100, 1995–2025. M. R. (2009) Severe oral mucositis associated with cancer therapy: impact on oral functional status and quality of life. Supportive Care in Cancer, 18, 1477–1485. B. et al. (2003) Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review.
Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients by Mario E. Lacouture