Cytokines (Handbook of Immunopharmacology) by Anthony R. Mire-Sluis, Robin Thorpe PDF

By Anthony R. Mire-Sluis, Robin Thorpe

ISBN-10: 0124983405

ISBN-13: 9780124983403

ISBN-10: 1435608062

ISBN-13: 9781435608061

This publication offers complete assurance of the cytokines from a pharmacological technique. The chapters are offered in a constant layout permitting effortless cross-reference, with pattern diagrams and a precis desk of crucial evidence for every bankruptcy on the finish of the book.Cytokines is exclusive in stressing cytokine biology and the applying of analysis info to supply affliction treatment. With 33 special and up to date chapters approximately person cytokines, this accomplished reference will offer either clinicians and researchers in immunology and pharmacology with worthy info. Key positive aspects* Genetic info and sequences* Protein constitution* phone assets and creation* organic job* Cytokine receptor constitution and sign transduction* dialogue of the position of cytokines in sickness and the opportunity of treatment* precis desk of crucial proof* accomplished bibliography

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Extra info for Cytokines (Handbook of Immunopharmacology)

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In spite of limited sequence similarity, IL-10~ and IL-113 have similar threedimensional structure, consisting of a ~-barrel with four triangular faces forming a tetrahedron. A number of sitederived mutagenesis studies have been attempted to identify critical residues for receptor binding and NH --COOH The arrow before Arg 2s indicates the position of the mature NH 2 terminal after removal of the leader peptide. Asn glycosylation sites are marked in bold circles. 113, and (c) human IL-1Ra. Glycosylation sites and the ICE cleavage site of IL-113 are indicated.

1993a). To validate the decoy model of action of IL-1RII, we overexpressed this receptor in type I-expressing human fibroblasts. As expected, IL-1 activity was reduced in fibroblasts expressing high levels of IL-1RII. , 1996). , 1993) is in keeping with the concept that the IL1RII may represent a physiological pathway of inhibition of IL-1. Induction of expression and release of the IL1RII may contribute to the anti-inflammatory properties of TH2-derived cytokines and GC. 7. , 1990). In certain cellular systems, but not in others, elevations of cAMP have been reported after exposure to IL-1.

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80, 2012. , et al. (1993a). Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science 261,472. , et al. (1993b). Type II interleukin-1 receptor is not expressed in cultured endothelial cells and is not involved in endothelial cell activation. Blood 81, 1347. E. and Mantovani, A. (1994a). The type II "decoy" receptor: novel regulatory pathway for interleukin-1.

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Cytokines (Handbook of Immunopharmacology) by Anthony R. Mire-Sluis, Robin Thorpe

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