By Richard Beliveau
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Q. once or twice weekly (twice-weekly dose is higher than 20 units each or likely to cause serious toxic reactions of the skin) or ⋅ Use 15 to 20 units/m2 daily for 3 to 7 days by continuous infusion or ⋅ Use 60 units/m2 dissolved in 100 mL of normal saline for intracavitary therapy. • Mitomycin (Mutamycin) ♦ Indications. Gastric carcinoma, pancreatic carcinoma. ♦ Pharmacology ◊ Mechanism. After enzyme activation in the tissues, it functions as a bifunctional or trifunctional alkylating agent. It causes cross-linking of DNA, inhibits DNA synthesis, and to a lesser extent also inhibits RNA and protein synthesis.
Dose. From 20 to 60 mg/m2/day for 5 days or 100 mg/m2 once or twice weekly. C. Enzymes • L-Asparaginase (Elspar; Kidrolase) ♦ Indications. ALL. ♦ Pharmacology ◊ Mechanism. Most normal tissues synthesize L-asparagine in amounts sufficient for protein synthesis. Certain neoplastic tissues, including ALL cells, require an 37 38 exogenous source of this amino acid. L-Asparaginase deprives these cells of the asparagine available from extracellular fluid by catalyzing the hydrolysis of L-asparagine to aspartic acid and ammonia.
Daily for 3 days every 3 to 4 weeks. v. weekly. • Idarubicin (Idamycin)/epirubicin (Ellence) ♦ Indications. AML. ♦ Pharmacology. Idarubicin and epirubicin are anthracycline glycosides. They may intercalate DNA strands, inhibit DNA synthesis, interact with RNA polymerases, and inhibit topo II. They are more lipophilic than other anthracycline antibiotics. 33 ♦ Toxicity similar to that of doxorubicin. ♦ Administration. v. injection over a 5-minute period with extravasation precautions is mandated.
Cuisiner avec les aliments contre le cancer by Richard Beliveau