By G. Stenman, J. Bullerdiek, S. Bartnitzke, P. Sahlin, E. Röijer, J. Mark (auth.), Prof. Dr. J. Bullerdiek, Dr. S. Bartnitzke (eds.)
Researchers considering the cytogenetics and molecular genetics of human tumors will welcome this complete evaluation of the kind of aberrations that chromosome 12 offers in human sturdy tumors. The authors examine the consequences for a cytogenetic subtyping of the tumors concerned and methods for deciding upon the molecular alterations which underlie the karyotypic changes.
The aberrations of chromosome 12 which the ebook offers with are very common chromosomal adjustments in human tumors occuring in common benign mesenchymal tumors, akin to uterine leiomyomas and lipomas, and in tumors of epithelial foundation, equivalent to pleomorphic adenomas of the salivary glands.
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Additional resources for Chromosome 12 Aberrations in Human Solid Tumors: Cytogenetics and Molecular Genetics
Springer, Berlin Heidelberg New York Lipoma Cytogenetics N. Mandahl 1 Introduction The occurrence of nonrandom clonal cytogenetic abnormalities in tumor cells has been unequivocally demonstrated (Heim and Mitelman 1987; Sandberg 1990). It should, however, be stressed that the data are heavily biased in favor of hematologic neoplasms; of the total data base comprising 14141 human tumors reported to have clonal chromosome aberrations, 68% involve hematologic disorders, 11 %, lymphomas, and 21 %, solid tumors (MiteIman 1991).
However, if factors exist determining the prob ability of a band to become a breakpoint, it should be worthwhile to test not only the breakpoints, but also the number of individual breaks at each breakpoint. Again, no significant correlation between the breaks and the location of fragile sites was found, indicating that as a rule the breaks in these tumors occur independently of fragile sites. Although the fact that Giemsa-light bands are the preferential target of breakpoints as weIl as of break events offers strong evidence that an open chromatin cdnfiguration increases its probability to participate in a chromosomal rearrangement in these tumors, the causative agent(s) of these rearrangements remain to be elucidated.
Virchows Arch [B]57:77-79 Heim S, Nilbert M, Vanni R, Floderus V-M, Mandahl N, Liedgren S, Lecca V, Mitelman F (1988) A specific translocation, t(12;14)(q14-15;q23-24), characterizes a subgroup of uterine leiomyomas. Cancer Genet Cytogenet 32:13-17 Hli J, Surti V (1991) Subgroups of uterine leiomyomas based on cytogentic analysis. Hum Pathol 22: 1009-1016 Kiechle-Schwarz M, Berger CS, Surti V, Sandberg AA (1990) Rearrangement of band lOq22 in leiomyoma and leiomyosarcoma of the uterus. Cancer Genet Cytogenet 47:95-100 Kiechle-Schwarz M, Sreekantaiah C, Berger CS, Pedron S, MedchiII MT, Surti V, Sandberg AA (1991a) Nonrandom cytogenetic changes in leiomyomas of the female genitourinary tract - areport of 35 cases.
Chromosome 12 Aberrations in Human Solid Tumors: Cytogenetics and Molecular Genetics by G. Stenman, J. Bullerdiek, S. Bartnitzke, P. Sahlin, E. Röijer, J. Mark (auth.), Prof. Dr. J. Bullerdiek, Dr. S. Bartnitzke (eds.)