Chromosomal Instability and Aging: Basic Science and - download pdf or read online

By Fuki Hisama, Sherman M. Weissman, George M. Martin

ISBN-10: 0824708563

ISBN-13: 9780824708566

This article examines the connection among DNA harm and service, mobile senescence, genomic instability and ageing. It contains in-depth discussions of varied forms of DNA harm, the DNA fix community, and mobile responses to genetic harm to evaluate their influence at the modulation of getting old approaches and age-related illness, together with melanoma improvement.

Show description

Read Online or Download Chromosomal Instability and Aging: Basic Science and Clinical Implications PDF

Best basic science books

The Biology of Musical Performance and Performance-Related - download pdf or read online

The Biology of Musical functionality and Performance-Related damage offers exact details at the organic ideas and actual approaches that underlie the craft of musical functionality. It explains ideas and strategies with out assuming past clinical wisdom, supplying relevance to either musicians and healthiness execs who deal with performance-related health conditions.

Read e-book online Neonatology Questions and Controversies Series: PDF

This fascinating new reference brings you information regarding the main arguable gastroenterology and food demanding situations you face on your perform. The publication optimistically tackles those matters and provides professional suggestion at the most up-to-date diagnostic and therapy techniques utilizing evidence-based drugs anyplace attainable.

Embryologie : Entwicklungsstadien : Frühentwicklung ; by Stefan Elsberger, Keith Moore, T. V. N. Persaud, Mark G. PDF

Kurzbeschreibung Der Embryologie-Klassiker in neuer Auflage! Die deutsche Übersetzung des englischen Klassikers ist ein umfassendes Lehrbuch zur Embryologie und Teratologie des Menschen, das darüber hinaus auch noch klinisch orientiert die Sachverhalte näher bringt. Woche für Woche, Stadium für Stadium erfahren Sie, wie sich die Organe und Systeme entwickeln und wann und wie Fehlbildungen entstehen.

Cosmetic lipids and the skin barrier by Thomas Forster PDF

Targeting new biophysical and analytical equipment that may check lipid prestige and the development of pores and skin situation, this reference offers crucial quantitative details at the interplay of topically utilized lipids with dermis barrier lipids. Containing contributions from across the world well-known experts and over one thousand references, drawings, pictures, and tables, it explores how diversified lipid types functionality in beauty formulations and at the epidermis.

Extra resources for Chromosomal Instability and Aging: Basic Science and Clinical Implications

Sample text

2. Threshold Expression Different organs in the human body have different requirements for mitochondrial energy metabolism. It is generally agreed that the brain, heart, and skeletal muscle have the highest energy demands followed by the kidneys, endocrine system, and liver (34). The phenotypic expression of a pathological mtDNA mutation will be determined by the relative proportion of wild-type versus mutant mitochondria in a given tissue. The percentage of mutant mtDNAs needed to impair energy metabolism enough to cause organ dysfunction is called the threshold effect (35).

If neither the p53 nor the pRB pathway is intact, cells may survive with genomic rearrangements and instability, which can lead to cancer and possibly other aging phenotypes. Both apoptosis and cellular senescence suppress tumorigenesis in mammals. However, whereas apoptosis kills and eliminates potential cancer cells, cellular senescence permanently arrests their growth. Recent findings have shed new light on the causes of cellular senescence, the complexity of the senescent phenotype, and the potential consequences of cellular senescence for the development of cancer and aging phenotypes in mammalian organisms.

The effect of donor age on the processing of UV-damaged DNA by cultured human cells: reduced DNA repair capacity and increased DNA mutability. Mutat Res 364:117–123, 1996. D Goukassian, F Gad, M Yaar, MS Eller, US Nehal, BA Gilchrest. Mechanisms and implications of the age-associated decrease in DNA repair capacity. FASEB J 14:1325–1334, 2000. CB Harley, AB Futcher, CW Greider. Telomeres shorten during ageing of human fibroblasts. Nature 345:458–460, 1990. ND Hastie, M Dempster, MG Dunlop, AM Thompson, DK Green, RC Allshire.

Download PDF sample

Chromosomal Instability and Aging: Basic Science and Clinical Implications by Fuki Hisama, Sherman M. Weissman, George M. Martin


by Robert
4.2

Rated 4.18 of 5 – based on 44 votes

Categories: Basic Science