By Marja Makarow, Ineke Braakman
Molecular chaperones engage with nearly each newly synthesized protein. This quantity assembles a suite of experiences on molecular chaperones that's either well timed and easy. The publication uniquely combines the fundamentals of the topic sector with the most recent effects. This makes it a good front for rookies into the sector and is acceptable for instructing reasons. It additionally offers a resource of considerable info for specialists.
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Extra info for Chaperones (Topics in Current Genetics)
Mol Biol Cell 12:3502-3514 Denegri M, Moralli D, Rocchi M, Biggiogera M, Raimondi E, Cobianchi F, De Carli L, Riva S, Biamonti G (2002) Human chromosomes 9, 12, and 15 contain the nucleation sites of stress-induced nuclear bodies. Mol Biol Cell 13:2069-2079 Eriksson M, Jokinen E, Sistonen L, Leppä S (2000) Heat shock factor 2 is activated during mouse heart development. Int J Dev Biol 44:471-477 Fargnoli J, Kunisada T, Fornace AJ Jr, Schneider EL, Holbrook NJ (1990) Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats.
Exp Cell Res 248:30-43 Kallio M, Chang Y, Manuel M, Alastalo TP, Rallu M, Gitton Y, Pirkkala L, Loones MT, Paslaru L, Larney S, Hiard S, Morange M, Sistonen L, Mezger V (2002) Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice. EMBO J 21:2591-2601 Kawazoe Y, Nakai A, Tanabe M, Nagata K (1998) Proteasome inhibition leads to the activation of all members of the heat-shock-factor family. Eur J Biochem 255:356-362 Kline MP, Morimoto RI (1997) Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation.
It will be of great interest to learn to what extent and by which mechanisms the HSFs interact with other transcriptional activators and repressors to mediate these multi-faceted regulatory programs. Localization of HSFs into the nuclear stress bodies has underlined the importance of subnuclear localization in the regulation of transcription. Furthermore, the surprising findings of HSF1-mediated transcription of satellite III repeats within the 9q12 locus and the recruitment of proteins involved in mRNA metabolism have raised possibilities of novel roles for HSF1 as an indirect regulator of mRNA splicing and/or heterochromatin assembly (for review see Biamonti 2004).
Chaperones (Topics in Current Genetics) by Marja Makarow, Ineke Braakman