By Otmar D. Wiestler (Editor), Bernhard Haendler (Editor), Dominik Mumberg (Editor)
Melanoma stem cells have initially been pointed out in leukemia and later in numerous good tumor varieties. they've got very varied homes from the majority of the tumor as they divide even more slowly and feature very effective drug resistance mechanisms. present remedies may well mostly spare melanoma stem cells. This e-book appears at fresh advancements within the box of melanoma stem cells and the prospective effect for the identity of novel remedy paradigms for melanoma.
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Extra info for Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy (Ernst Schering Foundation Symposium Proceedings 06.5)
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 28 29 30 31 35 37 37 39 40 41 42 42 44 46 47 Abstract. The Wnt signal transduction pathway plays important roles during embryo development, regulating cell proliferation and survival of immature cells. However, its improper function can lead to harmful consequences for humans, such as aberrant cell proliferation and, therefore, cancer. Increasing evidence suggests that stem cells may be the source of mutant cells that cause cancers to develop and proliferate.
2001). Similarly, only 1 adenocarcinoma of 90 primary lung cancers and 3 of 76 lung cancer cell lines studied to date have been reported to have a mutation (Shigemitsu et al. 2001). In another study, none of the 93 lung cancer cells analyzed displayed the mutations (Ueda et al. 2001). Only fetal-type adenocarcinomas, a rare subtype of lung cancer, appear to more consistently possess the activating β-catenin mutations (Nakatani et al. 2002). Based on these studies, it appears that β-catenin, in and of itself, plays less of a role in lung carcinogenesis than in other malignancies, particularly colorectal cancer.
18 4 A. Trumpp The Role of Endogenous c-Myc in Ras-Mediated Skin Tumorigenesis The two-stage carcinogenesis assay has been used for many decades as a framework to study the multistage nature of cancer development (DiGiovanni 1992). This assay is based on the exposure of shaved mouse skin to the mutagen DMBA (7,12-dimethylbenz[a]anthracene) (tumor initiation), followed by repeated TPA treatment (tumor promotion). After the latency of several weeks, a large number of benign papillomas develop, of which about 10% progress to malignant squamous cell carcinomas.
Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy (Ernst Schering Foundation Symposium Proceedings 06.5) by Otmar D. Wiestler (Editor), Bernhard Haendler (Editor), Dominik Mumberg (Editor)