Read e-book online Cancer Genomics PDF

By L. A. Cannizzaro

ISBN-10: 3805584334

ISBN-13: 9783805584333

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Stallings RL, Nair P, Maris JM, Catchpoole D, McDermot M, et al: High resolution analysis of chromosome breakpoints and genomic instability identifies PTPRD as a candidate tumor suppressor gene in neuroblastoma. Cancer Res 66:3673–3680 (2006). Stark B: der(11)t(11;17): a distinct cytogenetic pathway of advanced stage neuroblastoma (NBL) – detected by spectral karyotyping (SKY). Cancer Lett 197:75–79 (2003). Upender MB, Habermann JK, McShane LM, Korn EL, Barrett JC, et al: Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells.

Saglio G, Storlazzi CT, Giugliano E, Surace C, Anelli L, et al: A 76-kb duplicon maps close to the BCR gene on chromosome 22 and the ABL gene on chromosome 9: possible involvement in the genesis of the Philadelphia chromosome translocation. Proc Natl Acad Sci USA 99:9882–9887 (2002). Sato M, Takahashi K, Nagayama K, Arai Y, Ito N, et al: Identification of chromosome 9p as the most frequent target of homozygous deletions in lung cancer. Genes Chromosomes Cancer 44: 405–414 (2005). Sebat J, Lakshmi B, Troge J, Alexander J, Young J, et al: Large-scale copy number polymorphism in the human genome.

The chemokines and their receptors are a family of small secreted molecules that regulate the migration around the body of cells in the lymphoid system, a process that shares many characteristics with the successful dissemination of tumor cells in the body. Chemokine receptors are G-protein-coupled cell surface proteins expressed on leukocytes and many nonhematopoietic cells. These receptors bind various chemokines that are constitutively expressed in distinct tissue microenvironments. The chemokine CXCL1 and the chemokine receptor CXCR4 are present in the signature intersect gene list (Table 1).

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Cancer Genomics by L. A. Cannizzaro


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