Download e-book for iPad: Cancer Cytogenetics: Methods and Protocols by John Swansbury (auth.), John Swansbury (eds.)

By John Swansbury (auth.), John Swansbury (eds.)

ISBN-10: 1588290808

ISBN-13: 9781588290809

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Extra info for Cancer Cytogenetics: Methods and Protocols

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Brecher, M. , Green, D. , and Sandberg, A. A. (1988) Translocation t(1;22) in congenital acute megakaryocytic leukemia. Cancer Genet. Cytogenet. 34, 277–280. 35. , et al. (1991) The t(1;22) (p13;q13) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: a Pediatric Oncology Group Study. Blood 78, 748–752. 36. , et al. (1997) The significance of trisomy 8 in de novo acute myeloid leukemia: the accompanying chromosome aberrations determine the prognosis. Br. J. Haematol. 99, 605–611.

Another translocation involving the same gene on chromosome 17 plus the PLZF gene at 11q23 is the t(11;17)(q23;q21), which can 34 Swansbury Fig. 2. Cell from a case of AML M3 in which all the diploid metaphases found were normal and all the tetraploid metaphases were too poor for full analysis. However, the typical t(15;17)(q24;q21) could still be recognized; the abnormal chromosomes are indicated with arrows. also occur with a diagnosis of M3 (28). However, these patients do not respond in the same way to ATRA.

J. Haematol. 99, 925–928. 41. Langabeer, S. , Gale, R. , et al. (1997b) Frequency of CBFbeta/MYH11 fusion transcripts in patients entered into the U. K. MRC AML trials. Br. J. Haematol. 96, 738–739. 42. , Cotterill, S. , Ross, F. , et al. (2000) Cytogenetically cryptic AML1/ETO and CBFB/MYH11 gene rearrangements: incidence in 412 cases of acute myeloid leukemia. Br. J. Haematol. 111, 1051–1056. 43. , Powles, R. , et al. (1999) Outcome of biphenotypic acute leukemia. Hematologica 84, 699–706. 44.

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Cancer Cytogenetics: Methods and Protocols by John Swansbury (auth.), John Swansbury (eds.)


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