Cancer Chemotherapy by Alan C. Sartorelli (Eds.) PDF

By Alan C. Sartorelli (Eds.)

ISBN-10: 0841203105

ISBN-13: 9780841203105

ISBN-10: 0841203369

ISBN-13: 9780841203365

content material: improvement of [alpha]-(N)-heterocyclic carboxaldehyde thiosemicarbazones with medical capability as antineoplastic brokers / Alan C. Sartorelli and Krishna C. Agrawal --
Adriamycin / David W. Henry --
Biochemical pharmacology of the anthracycline antibiotics / Nicholas R. Bachur --
power bioreductive alkylating brokers / Ai Jeng Lin, Lucille A. Cosby, and Alan C. Sartorelli --
A overview of reviews at the mechanism of motion of nitrosoureas / Glynn P. Wheeler.

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84. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1976. b 2. HENRY Adriamycin 29 a c t i v i t y i s r e t a i n e d a f t e r i n s e r t i o n of such a l a r g e and comp a r a t i v e l y nonpolar group. Carbonyl d e r i v a t i z a t i o n at C-13 a l s o causes a decrease i n potency i n animal t e s t s but the e f f e c t i s l e s s than with Na c y l a t i o n and the e f f i c a c y of the d e r i v a t i v e i s o c c a s i o n a l l y b e t t e r than the parent a n t i b i o t i c .

A n t i b i o t i c s k i n d l y provided by Dr. Martin Apple, UCSF. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1976. CANCER 32 CHEMOTHERAPY L a b o r a t o r i e s (106,107). These compounds, prepared from 14-bromodaunomycin by displacement with carboxylate s a l t s , f r e q u e n t l y Figure 5. Adriamycin-14-O-carboxylates prepared by Arcamone et al (106). R = CH , C H, n-C H , C H , CH C H,, 3-pyridyl, CH (l-naphthyl). 3 2 y 7 15 ft 5 2 6 2 d i s p l a y e d i n v i t r o and i n v i v o c y t o t o x i c e f f e c t s comparable to adriamycin.

Based upon the evidence reviewed above (and ô^T^so^e^^dliîa^nÎt d e s c r i b e d here) Arcamone and D i Marco (51) concluded that DNA-adriamycin complex i n v o l v e s three types of b i n d i n g : hydrophobic i n t e r a c t i o n due to the i n t e r c a l a t e d a g l y cone, e l e c t r o s t a t i c a t t r a c t i o n between the protonated 3'-amino group of the daunosamine and phosphate groups of the h e l i x , and hydrogen bonds of u n s p e c i f i e d c h a r a c t e r . The molecular model proposed by Pigram et a l .

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Cancer Chemotherapy by Alan C. Sartorelli (Eds.)

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Categories: Oncology