Breast Cancer: Prognosis, Treatment, and Prevention, Second - download pdf or read online

By R. Pasqualini Jorge

ISBN-10: 142005872X

ISBN-13: 9781420058727

Now in its moment version, this bestselling name has been largely revised and accelerated to incorporate new subject matters on:

  • obesity and breast cancer
  • induction of anti-hormone and anti-growth issue resistance in breast cancer
  • clinical implications of testosterone and breast cancer
  • insulin-like development factors
  • discussions at the organic, genetic, and molecular pathways associated with the improvement and development of breast cancer
  • analyses at the newest healing options, prognostic and predictive components, and prevention strategies

Examining new advancements, Breast melanoma: analysis, therapy, and Prevention, moment Edition additionally covers:

  • the mechanism concerned with carcinogenesis
  • the courting between a fetus, being pregnant, and breast cancer
  • recent advancements in endocrine treatment
  • the courting between hormone alternative remedy, cytotoxic treatment, and different non-hormonal techniques for the therapy of metastases
  • management of in the community complicated breast melanoma, and the significance of BRCA-1 and BRCA-2 in hereditary breast cancer

With new themes and up-to-date chapters, this re-creation retains either oncologists and radiologists abreast of the present traits and developments within the diagnosis, remedy, and prevention of breast cancer.

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Extra resources for Breast Cancer: Prognosis, Treatment, and Prevention, Second Edition

Sample text

Patients whose tumors presented no SULT activity failed to respond to adrenalectomy and had a poor prognosis (Pewnim et al. 1982; Adams et al. 1989; Luu-The et al. 1996). SULTs expression and progestins A study on the effects of the progestin promegestone (R-5020) on hEST1, now named SULT1A3, mRNA and the formation of estrogen sulfates in the T-47D and MCF-7 cells showed that at low doses of R-5020 there was a significant increase of mRNA levels in these breast cancer cell lines. This was accompanied by an increased formation of estrogen sulfates in these cell lines following the treatment.

Parabens ( p-hydroxybenzoate esters) are a group of preservatives widely used in cosmetics, food, and pharmaceutical products, which can exhibit estrogenic effects in animal models. Prusakiewicz et al. (2007) demonstrate an inhibitory effect of the EST activity present in skin cytosol. Butylparaben, the most potent inhibitor, has an IC50 value of 37 mM. The authors suggest that SULTs inhibition by parabens could stimulate or prolong estrogen signaling cascades by elevating the levels of E2 and E1.

60- A resolution. In this connection, it is interesting to mention that Pizzagalli et al. (2003) found the organic anion transporting polypeptide OATP-B (SLCZ1A9) to be the most functionally relevant steroid sulfate carrier present and is able to account for delivery of both estrogen sulfate and DHEA-S to normal and tumoral breast tissues. , 2005). , 2004). Using total breast cancer tissues from postmenopausal patients, it was shown that nomegestrol acetate or medrogestone can block the sulfatase activity.

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Breast Cancer: Prognosis, Treatment, and Prevention, Second Edition by R. Pasqualini Jorge


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Categories: Oncology