By K. J. Zülch M.D. (auth.)
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Additional info for Brain Tumors: Their Biology and Pathology
H. E. MARSHALL and F. B. SMITH: Microgliomatosis: Form of reticulosis affecting the brain. Brain 71, 1-15, 1948. BRAIN TUMORS 30 B. MESODERMAL TUMORS The meningiomas: The meningiomas are the most important representatives of the mesodermal tumors. Macroscopically uniform, they can be subdivided histologically into three, ten or 22 subtypes. Biologically, as Cushing himself admitted (Cushing and Eisenhardt), this subdivision has no significance. We are content, therefore, to recognize three subtypes, for which the traditional names still seem suitable-endotheliomatous, fibromatous and angiomatous.
He explains the appearance of carcinomas partly by loss of the ability to differentiate, an involutional occurrence based probably on a chemical alteration of the cells. A "carcinoma signifies a catastrophe of form, and the essential nature of form is its capacity for differentiation and thus restriction of growth .... " Willis (1953, p. 199), to quote only one of the better-known tumor pathologists, adheres to a similar view of modern biology (Nicholson, 1933) which sees in tumor formation essentially an alteration of the normal relationship between growth and inhibition.
Astrocytomas: The astrocytoma group used to consist of three subgroupings: the protoplasmic, fibrillary, and gigantocellular types, to which I have added a fourth, the astroblastoma. The latter is difficult to distinguish macroscopically and has the same biological significance. The malignant astrocytoma forms the fifth subgrouping. It includes cases which still have the characteristics of astrocytomas but also are beginning to show a malignant degeneration in several regions that imperceptibly shades into glioblastomas.
Brain Tumors: Their Biology and Pathology by K. J. Zülch M.D. (auth.)