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By Laura Dower

Princess Morbucks, the Powerpuff ladies' least favourite kindergartner, has get a hold of one other dastardly scheme to thwart Blossom, Bubbles, and Buttercup. She's acquired Townsville from the Mayor and made crime felony! Now the ladies are pressured to face apart as criminals parade during the urban, robbing shops, littering, and making infants cry. Can brainy Blossom ponder the way to outwit Princess? Or is Townsville doomed to develop into Crimesville?

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There has been considerable recent interest in the potential role of ICC disorders in the pathogenesis of human gut motility disorders (reviewed by Burns [17]) and loss and reduced ICC numbers have been implicated in Hirschsprung’s disease, slow transit constipation, chronic intestinal pseudo-obstruction, and esophageal achalasia. Some debate exists over whether there is true loss of ICCs, de-differentiation or loss of the cell surface receptor that defines ICCs c-kit. ICCs appear capable of transdifferentiation to smooth muscle 7 cells, a cell type with which they share the same mesenchymal progenitor.

Pediatr Dev Pathol. 2002;5:224–47. 7. Chalazonitis A, Rothman TP, Chen J, Vinson EN, MacLennan AJ, Gershon MD. Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. Dev Biol. 1998;198:343–65. 8. Schafer KH, Hansgen A, Mestres P. Morphological changes of the myenteric plexus during early postnatal development of the rat. Anat Rec. 1999;256:20–8. 9. Faussone-Pellegrini MS, Matini P, Stach W. Differentiation of enteric plexuses and interstitial cells of Cajal in the rat gut during pre- and postnatal life.

1996;111:901–10. 102. Horisawa M, Watanabe Y, Torihashi S. Distribution of c-Kit immunopositive cells in normal human colon and in Hirschsprung’s disease. J Pediatric Surg. 1998;33:1209–14. 103. Newman CJ, Laurini RN, Lesbros Y, Reinberg O, Meyrat BJ. Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung’s disease. Pediatric Surg Int. 2003;19:662–8. 104. Ward SM, Ordog T, Bayguinov JR, et al. Development of interstitial cells of Cajal and pacemaking in mice lacking enteric nerves.

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Bought and Scold by Laura Dower


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