Download e-book for iPad: Blistering Diseases: Clinical Features, Pathogenesis, by Dédée F. Murrell

By Dédée F. Murrell

ISBN-10: 3662456974

ISBN-13: 9783662456972

ISBN-10: 3662456982

ISBN-13: 9783662456989

This booklet is a complete compendium of present wisdom on inherited and autoimmune blistering ailments that relates advances in our realizing of the pathogenetic mechanisms to administration of the person illnesses. the purpose is to supply an in depth reference for dermatologists who deal with sufferers with those stipulations and an invaluable “one-stop info store” for experts outdoors of dermatology. The booklet opens through describing the constitution and biology of the pores and skin and basement membrane sector and discussing the genes and proteins which are ambitions for mutations and autoantibodies. The function of a few of the diagnostic assessments is defined, and scientific manifestations of the explicit ailments are offered due to many top quality illustrations. The kinds of therapy applicable in particular stipulations are then defined intensive, with assurance of dressings, medications, surgeries, gene treatment, and different novel ways. necessary algorithms are incorporated either for checking out and tracking and for treatment.

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J Biol Chem. 1996;271(23):13739–45. 60. Schumann H, Baetge J, Tasanen K, Wojnarowska F, Schacke H, Zillikens D, et al. The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases. Am J Pathol. 2000;156(2):685–95. 61. Borradori L, Chavanas S, Schaapveld RQ, GagnouxPalacios L, Calafat J, Meneguzzi G, et al. Role of the bullous pemphigoid antigen 180 (BP180) in the assembly of hemidesmosomes and cell adhesion— reexpression of BP180 in generalized atrophic benign epidermolysis bullosa keratinocytes.

119. 120. 121. 122. 123. 124. 125. 126. 127. 128. 129. (COL7A1) in Hallopeau-Siemens dystrophic epidermolysis bullosa. Nat Genet. 1993;5(3):287–93. Christiano AM, Greenspan DS, Hoffman GG, Zhang X, Tamai Y, Lin AN, et al. A missense mutation in type VII collagen in two affected siblings with recessive dystrophic epidermolysis bullosa. Nat Genet. 1993;4(1):62–6. Uitto J, McGrath JA, Rodeck U, Bruckner-Tuderman L, Robinson EC. Progress in epidermolysis bullosa research: toward treatment and cure.

2008;128:2815–9. 79. Ashton GH, Sorelli P, Mellerio JE, Keane FM, Eady RA, McGrath JA. alpha6beta4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia. Br J Dermatol. 2001;144(2):408–14. 80. Baker SE, Hopkinson SB, Fitchmun M, Andreason GL, Frasier F, Plopper G, et al. Laminin-5 and hemidesmosomes: role of the alpha3 chain subunit in hemidesmosome stability and assembly. J Cell Sci. 1996;109(10):2509–20. 81. Rousselle P, Keene DR, Ruggiero F, Champliaud MF, Rest M, Burgeson RE.

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Blistering Diseases: Clinical Features, Pathogenesis, Treatment by Dédée F. Murrell

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Categories: Dermatology