Biological Effects of Alcohol - download pdf or read online

By Henri Begleiter (eds.)

ISBN-10: 1468436325

ISBN-13: 9781468436327

ISBN-10: 1468436341

ISBN-13: 9781468436341

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Biol. Chem. 246: 1872-1876, 1971. 46. M. D. Binding of 5'--guanylyl-· imidodiphosphate to turkey erythrocyte memoranes and effects on f3-'adrenergic-activated adenyl ate cyclase. J. Bioi. Chem. f5, 1974. 47. Pfeiffer, T. t·1. Activation of pigeon erythrocyte membrane andenylate cyclase by guanylnucleotide analogs and separation of a nucleotide binding protein. J. Bioi. Chem. 250: 867-876,1975. 48. Pecker, F. and Hanouve, J. Uncoupled f3-adrenergic receptors and adeny late cycl ase can be recoup I ed by a GTP-dependent cytosol ic factor.

Ays l'Litli particular enzymes (55). rane is an important factor in its response to nucleotides as wei I as to hormones. Cuatrecases et al. hich the hormone-receptor interaction increases the formation of the GTP-containing complex. Our finding of a decreased response of striatal adenylate cyclase to dopamine is not easi Iy explained by postulating a simple decrease in GTP levels during ethanol witRdrawal. as not ol5served Cl8}. Furthermore, based on this postulate, tile addition of ethanol in vitro would not be expected to normalize tile response to dopamine:--l)n the other hand, alterations in membrane structure whi ch di srupted the interactions l5etween hormone, GTP, and adenylate cyclase could account for tile ol5served results.

Barnes, E. L. The mechanism of activation of tyrosine hydroxylase with nerve stimulation: Involvement of cycl ic AMP. Fed. Proc. 36: 406, 1977. 82. R. H. Dopaminergic neurons-alterations. in the sensitivity of tyrosine hydroxylase to inhibition by endogenous dopamine after cessation of impulse flow. Biochem. Pharmacol. 25: 649-654, 1976. 83. L. D. Stimulation of rat striatal tyrosine hydroxylase by phosphol ipids and adenosine 3' ,5'-monophosphate. Arzneimittel-Forschung. 26: 22-24, 1976. 84.

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Biological Effects of Alcohol by Henri Begleiter (eds.)


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