By Lodovico Balducci (Editor), Martine Extermann (Editor)
Organic foundation of Geriatric Oncology highlights study matters which are particular to geriatric oncology within the box of carcinogenesis and melanoma prevention and remedy, in line with the biologic interactions of melanoma and age. It illustrates the good thing about the foundations of geriatrics within the administration of melanoma within the older person. This quantity presents a body of reference for practicioners of any specialties fascinated with the administration of older sufferers and for oncologists occupied with the administration of melanoma of older participants. it's a resource for easy and scientific scientists exploring the interactions and rising details of melanoma and getting older.
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It was shown also that in vivo biguanides inhibits an appetite 150,151 and serum levels of leptin and IGF-1 152. It was suggested that biguanides regulate energy balance of the organism at the fat tissue level 153. In general, results of bioguanides effects seem very similar to those of calorie restriction. BIOLOGICAL INTERACTIONS 41 42 V. ANISIMOV 8. CONCLUSION The incidence of cancer increases with age in humans and in laboratory animals alike, but patterns of age-related distribution of tumors is different for different tissues and different tumors.
P53 mediated apoptosis was suggested as a safeguard mechanism to prevent cell proliferation induced by oncogene activation 31. 3. AGING AND SUSCEPTIBILITY TO CARCINOGENESIS IN VITRO Some in vitro observations support the suggestion on accumulation in tissues of premalignant cells. 9% in cultures received from five to seven month old mice. A spontaneous transformation of bladder epithelium occurred only in the explants received from old donors 32. The aging of the tissue donor was associated with increased susceptibility of primary cultures of rat fibroblasts to transformation induced by SV-40 33.
The colon 38 adenocarcinoma growth was significantly inhibited in liver-specific IGF-1-deficient mice, whereas injections with recombinant human IGF-1 displayed sufficiently promoted the tumor growth and metastasing 142. A decrease of glucose utilization was found in the 3-month-old female progeny of rats exposed to NMU on the day of pregnancy 124,140. Postnatal treatment with biguanides started from the age of 2 months significantly inhibited the development of malignant neurogenic tumors in rats transplacentally exposed to NMU or NEU 143-I44.
Biological Basis of Geriatric Oncology (Cancer Treatment and Research) by Lodovico Balducci (Editor), Martine Extermann (Editor)