By Vasilis Vasiliou, Samir Zakhari, Helmut K. Seitz, Jan B. Hoek
In the new years, an important quantity of analysis has emerged connecting the hyperlink among alcohol and melanoma. the sphere has quickly complex, specially because the advanced connection among alcohol and melanoma has numerous certain sub components which are being investigated. This complaints quantity will include chapters established upon the presentation of the 2d foreign convention on Alcohol and melanoma in Colorado, 2013. some of the themes discover the impacts of alcohol on: liver and breast melanoma; mobilephone signaling and melanoma; stem cells; biomarkers and metabolomics; aerodigestive cancers; melanoma and the immune procedure and more.
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Extra resources for Biological Basis of Alcohol-Induced Cancer
03. No association was seen between lifetime alcohol intake and risk of breast cancer. No difference in risk was shown between users and nonusers of HRT, and there was no significant interaction between alcohol intake and BMI, HRT, or dietary folate . In summarizing the main outcomes of the epidemiological studies, despite the indications suggested by many of these studies that there is some relationship between alcohol use history and the risk for developing breast cancer, the nature of that relationship remains poorly characterized.
2 Alcohol and Breast Cancer: Reconciling Epidemiological and Molecular Data 23 Mitochondrial NADH is oxidized by the mitochondrial electron transport chain. Chronic alcohol consumption renders mitochondrial oxidative phosphorylation inefficient by interfering with the main respiratory complexes (Complex I, III, IV, and V) of the electron transport system encoded on mitochondrial DNA (mtDNA), resulting in the formation of the superoxide anion. In breast cancer, like in other cancers, mitochondrial function is severely impaired .
Acetaldehyde, produced by ethanol oxidation through any of these mechanisms, is rapidly metabolized mainly by mitochondrial aldehyde dehydrogenase (ALDH2) to form acetate and NADH and to a much lesser extent by ALDH1 in the cytosol. 2 Alcohol and Breast Cancer: Reconciling Epidemiological and Molecular Data 23 Mitochondrial NADH is oxidized by the mitochondrial electron transport chain. Chronic alcohol consumption renders mitochondrial oxidative phosphorylation inefficient by interfering with the main respiratory complexes (Complex I, III, IV, and V) of the electron transport system encoded on mitochondrial DNA (mtDNA), resulting in the formation of the superoxide anion.
Biological Basis of Alcohol-Induced Cancer by Vasilis Vasiliou, Samir Zakhari, Helmut K. Seitz, Jan B. Hoek
Categories: Basic Science