By Duncan Dartrey Adams
This publication describes how the Jerne-Burnet Forbidden Clone thought and the Adams-Knight H Gene thought, solved the pathogenesis and genetics of the autoimmune ailments exhibiting how particular immunotherapy and prophylaxis could be built. moreover, Ebringer's discovery of 2 microbial triggers of autoimmune illnesses is defined and the belief drawn that each one autoimmune illnesses have microbial triggers, so should be preventable by means of the discovering of the triggers and vaccination opposed to them.
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Extra resources for Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, Prophylaxis and Principles for Organ Transplantation
Thyroid autoimmun. New York: Plenum; 1987. p. l–10. 39. Adams DD. Long-acting thyroid stimulator: how receptor autoimmunity was discovered. Autoimmunity. 1988;1:3–9. 40. Knight A, Cague WS, Adams DD. Measurement of the thyroid-stimulating autoantibodies. In: Rose NR, Friedman H, editors. Manual of clinical immunology. 2nd ed. Washington: American Society for Microbiology; 1980. p. 391–402. 41. Jarrett EE, Miller HR. Production and activities of IgE in helminth infection. Prog Allergy. 1982;31:178–233.
Cytotoxic T cells kill virus-infected host cells and, in the form of forbidden clones, kill normal host cells, including the pancreatic islet b cells, causing Type 1 Diabetes [9, 10], pericytes, causing diabetic retinopathy [11, 12] and probably other autoimmune diseases with specific parenchymal cell destruction. (Fig. 3) Fig. , Adams has postulated that the pericytes are destroyed by forbidden clones of cytotoxic T cells, antigenicly-related to those that destroy the pancreatic islet b cells.
2006;177:3133–42. 22. Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutation of FOXP3. Nat Genet. 2001;7:20–1. 23. Sakaguchi S. Naturally-arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531–62. 24. Shevach EM. Organ-specfic autoimmunity. In: Paul WE, editor. Fundamental immunology. 4th edn. Philadelphia: Lippincott-Raven; 1999.
Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, Prophylaxis and Principles for Organ Transplantation by Duncan Dartrey Adams