Read e-book online Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, PDF

By Duncan Dartrey Adams

ISBN-10: 9400769369

ISBN-13: 9789400769366

ISBN-10: 9400769377

ISBN-13: 9789400769373

This publication describes how the Jerne-Burnet Forbidden Clone thought and the Adams-Knight H Gene thought, solved the pathogenesis and genetics of the autoimmune ailments exhibiting how particular immunotherapy and prophylaxis could be built. moreover, Ebringer's discovery of 2 microbial triggers of autoimmune illnesses is defined and the belief drawn that each one autoimmune illnesses have microbial triggers, so should be preventable by means of the discovering of the triggers and vaccination opposed to them.

Show description

Read or Download Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, Prophylaxis and Principles for Organ Transplantation PDF

Best genetics books

New PDF release: Medical Cytogenetics

The single monograph on cytogenetics for the pathologist, this up to the moment reference/text includes the main up to date examine findings on many very important themes in scientific genetics-notably FISH (fluorescent in situ hybridation)-based molecular cytogenetic applied sciences and spectral karyotyping. an outstanding source for cytogeneticists getting ready for the certifying exam in medical Cytogenetics provided via the yank Board of scientific Genetics (ABMG).

New PDF release: The Science and Applications of Microbial Genomics: Workshop

Over the last numerous a long time, new medical instruments and methods for detecting microbial species have dramatically improved our appreciation of the variety and abundance of the microbiota and its dynamic interactions with the environments in which those microorganisms dwell. the 1st bacterial genome used to be sequenced in 1995 and took greater than thirteen months of labor to accomplish.

Extra resources for Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, Prophylaxis and Principles for Organ Transplantation

Example text

Thyroid autoimmun. New York: Plenum; 1987. p. l–10. 39. Adams DD. Long-acting thyroid stimulator: how receptor autoimmunity was discovered. Autoimmunity. 1988;1:3–9. 40. Knight A, Cague WS, Adams DD. Measurement of the thyroid-stimulating autoantibodies. In: Rose NR, Friedman H, editors. Manual of clinical immunology. 2nd ed. Washington: American Society for Microbiology; 1980. p. 391–402. 41. Jarrett EE, Miller HR. Production and activities of IgE in helminth infection. Prog Allergy. 1982;31:178–233.

Cytotoxic T cells kill virus-infected host cells and, in the form of forbidden clones, kill normal host cells, including the pancreatic islet b cells, causing Type 1 Diabetes [9, 10], pericytes, causing diabetic retinopathy [11, 12] and probably other autoimmune diseases with specific parenchymal cell destruction. (Fig. 3) Fig. , Adams has postulated that the pericytes are destroyed by forbidden clones of cytotoxic T cells, antigenicly-related to those that destroy the pancreatic islet b cells.

2006;177:3133–42. 22. Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutation of FOXP3. Nat Genet. 2001;7:20–1. 23. Sakaguchi S. Naturally-arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004;22:531–62. 24. Shevach EM. Organ-specfic autoimmunity. In: Paul WE, editor. Fundamental immunology. 4th edn. Philadelphia: Lippincott-Raven; 1999.

Download PDF sample

Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, Prophylaxis and Principles for Organ Transplantation by Duncan Dartrey Adams


by Jason
4.1

Rated 4.15 of 5 – based on 5 votes

Categories: Genetics