[Article] Karate injuries in children and adolescents - download pdf or read online

By Merrilee N. Zetaruk, Mariona A. Violan, David Zurakowski, Lyle J. Micheli

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There has been considerable recent interest in the potential role of ICC disorders in the pathogenesis of human gut motility disorders (reviewed by Burns [17]) and loss and reduced ICC numbers have been implicated in Hirschsprung’s disease, slow transit constipation, chronic intestinal pseudo-obstruction, and esophageal achalasia. Some debate exists over whether there is true loss of ICCs, de-differentiation or loss of the cell surface receptor that defines ICCs c-kit. ICCs appear capable of transdifferentiation to smooth muscle 7 cells, a cell type with which they share the same mesenchymal progenitor.

Pediatr Dev Pathol. 2002;5:224–47. 7. Chalazonitis A, Rothman TP, Chen J, Vinson EN, MacLennan AJ, Gershon MD. Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. Dev Biol. 1998;198:343–65. 8. Schafer KH, Hansgen A, Mestres P. Morphological changes of the myenteric plexus during early postnatal development of the rat. Anat Rec. 1999;256:20–8. 9. Faussone-Pellegrini MS, Matini P, Stach W. Differentiation of enteric plexuses and interstitial cells of Cajal in the rat gut during pre- and postnatal life.

1996;111:901–10. 102. Horisawa M, Watanabe Y, Torihashi S. Distribution of c-Kit immunopositive cells in normal human colon and in Hirschsprung’s disease. J Pediatric Surg. 1998;33:1209–14. 103. Newman CJ, Laurini RN, Lesbros Y, Reinberg O, Meyrat BJ. Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung’s disease. Pediatric Surg Int. 2003;19:662–8. 104. Ward SM, Ordog T, Bayguinov JR, et al. Development of interstitial cells of Cajal and pacemaking in mice lacking enteric nerves.

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[Article] Karate injuries in children and adolescents by Merrilee N. Zetaruk, Mariona A. Violan, David Zurakowski, Lyle J. Micheli


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