By Edgar Haber
Issues lined contain: X-ray crystallography of ligands. Catalytic antibodies. Nature of the antigen. Antibody binding websites. Maturation of the immune reaction. Computational biochemistry of antibodies and T-cell receptors. Antigen-specific T-cell receptors and their reactions. Key beneficial properties * X-Ray Crystallography of Ligands * Catalytic Antibodies * Nature of the Antigen * Antibody Binding websites * Maturtion of the Immune reaction * Computational Biochemistry of Antibodies and * T-Cell Receptors * Antigen-Specific T-Cell Receptors and Their Reactions
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Additional resources for Antibodies and T-Cell Receptors,
1994), can (in association with a self MHC-I protein) elicit and react with CD8+ T cells. , 1994) have recently been shown to recognize peptides from nonmutated melanocyte-specific proteins in association with HLA-A2. The underlying requirement for all these responses to be productive is that the abundance of the naturally processed pepMHC complex be sufficient and the TCR affinity and kinetics be favorable (see Section VI). , macrophages, dendritic cells, B cells). Peptides that bind to MHC-I1 proteins generally arise from integral membrane proteins or from endocytosed proteins, either soluble or membraneassociated (Tables I and 11).
Measuring epitope densities of naturally processed (endogenous) peptides on the cells that produce them requires a different approach. , 1990a). , 1993). , 1995). , a reasonable next step will be to measure the abundance of these peptides in order to find out whether epitope densities commonly limit T-cell responses (Tsomides, 1995). E. TCR-PepMHC Engagement: An Afinity Model The intensity of the T-cell response has been widely assumed to be determined, in large measure, by TCR affinity for pepMHC complexes and the number of these complexes on target cells (epitope density).
TCR-PepMHC Engagement: An Afinity Model The intensity of the T-cell response has been widely assumed to be determined, in large measure, by TCR affinity for pepMHC complexes and the number of these complexes on target cells (epitope density). The preceding section dealt with epitope density; here we focus on TCR afinity. Since the TCR-pepMHC reaction approaches equilibrium rapidly (see Section VI,C), equilibrium constants for this reaction could govern the outcome of T cell-target cell encounters.
Antibodies and T-Cell Receptors, by Edgar Haber
Categories: Basic Science