By Weiming Xia, Huaxi Xu
Within the look for an efficient therapy for Alzheimer's illness, APP is a special version protein that illustrates the wide selection of easy and complicated characterization thoughts to be had.
Exploring a number of organic recommendations to elucidate the constitution and serve as of this transmembrane protein, this article offers each one process with exact, step by step protocols to accomplish reproducible effects and supply a framework for learning different membrane proteins.
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Additional resources for Amyloid precursor protein : a practical approach
2. 6 mmol) is added dropwise. The resulting mixture is stirred at 0˚C for 30 min. 4 mmol) is dissolved in a mixture of THF (tetrahydrofuran, 45 mL) and dichloromethane (180 mL) under N2 atmosphere. The resulting solution is cooled to –20˚C. 6 mmol). The resulting mixture is stirred for 5 min at –20˚C and the above solution of N,O-dimethylhydroxyamine is added to it. 2 Scheme for synthesis of Leu*Ala di-isostere. 5 hr; (i) Fmoc-OSu, aqueous NaHCO3, dioxane, 23oC, 8 hr (61%). 30 min and then warmed to 23˚C.
Acad. Sci. USA 95, 1770, 1998. 32. A. C. Amyloid precursor protein modulates the interaction of nerve growth factor with p75 receptor and potentiates its activation of trkA phosphorylation. Mol. Brain. Res. 56, 125, 1998. 33. Henry A. et al. Inhibition of platelet activation by the Alzheimer’s disease amyloid precursor protein. Br. J. Haematol. 103, 402, 1998. 34. J. MOLSCRIPT: a program to produce both detailed and schematic plots of proteins. J. Appl. Crystallogr. 24, 946, 1991. fm Page 41 Wednesday, November 3, 2004 3:20 PM 4 Analysis of Amyloid Precursor Protein Processing Protease β-Secretase: Tools for Memapsin 2 (β-Secretase) Inhibition Studies Gerald Koelsch, Vajira Weerasena, Dongwoo Shin, Arun K.
24, 946, 1991. fm Page 41 Wednesday, November 3, 2004 3:20 PM 4 Analysis of Amyloid Precursor Protein Processing Protease β-Secretase: Tools for Memapsin 2 (β-Secretase) Inhibition Studies Gerald Koelsch, Vajira Weerasena, Dongwoo Shin, Arun K. 6 Since Aβ is intimately related to the pathogenesis of Alzheimer’s disease, a great deal of interest surrounds the design and testing of memapsin 2 inhibitors. 6 nM. 10,11 These structures define the interactions of the protease active sites with the inhibitors and also predict the locations of the APP substrate binding positions during the hydrolysis.
Amyloid precursor protein : a practical approach by Weiming Xia, Huaxi Xu
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