By Robin Holliday
For hundreds of years humans were questioned by means of the inevitability of human getting older. for many of the second one half the 20 th century getting older remained a secret, or an unsolved organic challenge. on the finish of the twentieth century a outstanding medical discovery emerged. It was once no longer a unmarried discovery within the traditional feel, since it used to be in keeping with a sequence of vital interconnected insights over rather an extended time period. those insights made it attainable for the first actual time to appreciate the organic purposes for getting older in animals and guy. it might probably already be acknowledged, even if, that the numerous observations and insights that specify getting older usually are not authorized as verified wisdom for a very long time. the sphere continues to be filled with scientists, and non-scientists, who're simply satisfied to head on speculating concerning the 'mystery' of getting older. the purpose of this booklet is to dispel lack of know-how via explaining in non-technical language what are the explanations for getting older and the parable of over the top prolongation of lifestyles.
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Extra info for Aging: The Paradox of Life
The immune system depends on cell division, and this may be one reason for its decline during ageing. We also know that the repair of external wounds is slower is significantly slower in old people compared to young ones. Probably there are changes in internal tissues or organs, that are corrected or repaired less efficiently during ageing, and therefore contribute to general impairment. It is striking, however, that some of the most obvious manifestations of ageing do not contribute to the spectrum of changes that eventually cause our demise.
These are often most clearly seen in long-lived proteins. The crystallin proteins of the eye lens have already been mentioned. These are laid down during the formation of the lens, and never replaced. With time abnormalities accumulate. These include oxidation (by ROS), the cross-linking of different protein molecules, spontaneous changes in amino acids, or the attachment of sugars to proteins. Alternatively, the correct folding of the amino acids chain may change to produce what is known as a denatured, or partially denatured, molecule.
Cancer is, in effect, a disease of development, or a disease of stem cells. Something goes wrong, which means that the normal regulatory control, or controls, is lost. The cell becomes isolated from its neighbour, starts to divide, and continues to do so. Normal regulatory mechanisms are essential to prevent that happening. This regulation itself is a maintenance mechanism to prevent the body being taken over by rogue cells. There are genes called tumour suppressors which are part of the defences against cancer.
Aging: The Paradox of Life by Robin Holliday
Categories: Basic Science