By George Klein, George F. Vande Woude
The Advances in melanoma learn sequence presents worthwhile details at the interesting and fast-moving box of melanoma examine. This quantity provides awesome and unique studies on quite a few issues, together with gene expression in inherited breast melanoma, multiparameter analyses of phone cycle law in tumorigenesis, Rho GTPases in transformation and metastasis, the myc oncogene, genetic requisites for the episomal upkeep of oncogenic herpesvirus genomes, remedy of Epstein-Barr virus-associated malignancies with particular T cells, the function of glycogen synthase kinase-3 in melanoma, power immune activation and irritation within the pathogenesis of AIDS and melanoma, and molecular biology of Hodgkin's lymphoma. * Gene Expression in Inherited Breast melanoma * Multiparameter Analyses of CellCycle Regulatory Proteins in Human Breast melanoma: A Key to Definition of Separate Pathways in Tumorigenesis * Rho GTPases in Transformation and Metastasis * The myc Oncogene: Marvelously advanced * Genetic necessities for the Episomal upkeep of Oncogenic Herpevirus Genomes * remedy of Epstein-Barr Virus-Associated Malignancies with particular T Cells * function of Glycogen Synthase Kinase-3 in melanoma: legislation Wnts and different Signaling Pathways * persistent Immune Activation and irritation within the Pathogenesis of AIDS and melanoma * Molecular Biology of Hodgkin's Lymphoma
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Cyclin D1 has both CDK-dependent and -independent functions of importance for breast cancer (Bernards, 1999). , 2000). , 1997). Cyclin D1 can further bind to the transcription factor and Myb-like protein DMP1 and counteract the growth inhibitory effect of DMP1 in a CDK-independent manner (Hirai and Sherr, 1996; Inoue and Sherr, 1998). , 1992). Studies analyzing protein levels have shown somewhat contradictory results and its prognostic value has been disputed, but in a large study analyzing 345 primary breast cancer samples, cyclin D1 overexpression was clearly associated with improved survival for up to 20 years (Barnes, 1997).
Advances in Cancer Research, Vol. 84 by George Klein, George F. Vande Woude